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孙作东脑科学体系

发布时间：

2020-08-26

孙作东，1966年生，研究员，奥博医疗创始人，黑龙江省亚欧脑科学研究院院长，黑龙江省“生物医学电子学”领军人才梯队技术带头人，黑龙江省及哈尔滨市脑病康复治疗设备工程技术研究中心负责人，首批博士后创新创业实践基地负责人。

他自1994年至今，一直从事脑科学基础理论研究与脑病康复治疗设备研发工作，是国际上将经颅电刺激技术应用于脑病治疗上的第一人。他应用经颅电、经颅磁电刺激技术发明的系列脑病康复治疗设备——脑功能康复治疗仪、帕金森治疗仪、阿尔茨海默治疗仪、抑郁症治疗仪等，均为世界首创，被广泛地应用于脑神经疾病临床实践中，取得了显著的康复治疗效果。

为了阐明仪器设备治疗机理和重大脑病的发病原因，他应用物理生物学原理，从细胞分子水平相继提出了“脑细胞激活论”与“鸠子论”，建立了钾离子通道“折纸风车”模型，提出了细胞膜面积守恒定律以及离子不等量方程，对细胞生物电现象产生机制进行了科学合理的解释；从重大脑病的发病原因、发病机制到治疗方法、治疗机理，现已自成体系。

在应对神经元退行性变疾病（阿尔茨海默症、帕金森病等）领域，孙作东从理论到实践正在引领世界；他建立的钾离子通道“折纸风车”模型，以及提出的细胞膜面积守恒定律、离子不等量方程，正在国际生命科学界产生颠覆性影响；他的最新学术成果“神经元能产生电磁波”理论，颠覆了神经元与神经元之间“电→化学→电”传导信息的观点，为人类最终破解脑奥秘提供了理论支持。

孙作东研究员针对脑科学、脑计划的论述性文章及其理论支撑性论文，相继在美国医学科学期刊、国外及国内NSTL国家预印本平台、中科院科技论文预发布平台、国家教育部科技论文在线上正式发表或发布。

1. Neurons Can Generate Electromagnetic Waves

神经元能够产生电磁波

2. Interpretation of Action Potential Generation Mechanism in Cardiomyocytes by Potassium Channel “Origami Windmill”Model

用钾离子通道“折纸风车”模型阐释心肌细胞动作电位发生机制

3. Enlightening Point of View Based on Potassium Channel “Origami Windmill” Model

基于钾离子通道“折纸风车”模型的启发性观点

4. Conservation Law of Cell Bioelectricity Membrane Area and Ion Inequality Equation Based on Potassium Channel “Origami Windmill” Model

基于钾离子通道“折纸风车”模型的细胞生物电膜面积守恒定律及离子不等量方程

5. Potassium channel Origami windmill Model

钾离子通道“折纸风车”模型

6. Interpretation of Action Potential Generation Mechanism in Cells by Potassium Channel "Origami Windmill" Model

用钾离子通道“折纸风车”模型阐释细胞动作电位发生机制

7. The Theory of Dove-like Particles

8. Revision and Supplement of the Theory of Dove-like Particles

鸠子论的修订与补充

9. The theory of brain cell activation

脑细胞激活论

10.Clinical Study on Transcranial Magnetoelectric Encephalopathy Therapeutic Apparatus in the Treatment of Parkinson’s Disease

经颅磁电脑病治疗仪治疗帕金森病的临床研究

11.Clinical Study on Transcranial Magnetoelectric Encephalopathy Therapeutic Instrument for the Treatment of Alzheimer’s Disease

经颅磁电脑病治疗仪治疗阿尔茨海默病的临床研究

12.Clinical Study on Transcranial Magnetoelectric Encephalopathy Therapeutic Instrument for Vascular Dementia

经颅磁电脑病治疗仪治疗血管性痴呆的临床研究

13.Clinical Study on Transcranial Magnetoelectric Depression Therapeutic Instrument for Depression

经颅磁电抑郁症治疗仪治疗抑郁症的临床研究

14.Effect of Aobo Cerebral Rehabilitation Therapeutic Apparatus on Cerebral Circulation and Cerebral Function

奥博脑复康治疗仪对脑循环和脑功能的影响

15.Effects of Brain Function Rehabilitation Apparatus (BFRA) on Cerebral Circulation and Cerebral Funct

脑功能康复仪（脑康仪）对脑循环和脑功能的影响

16. 脑功能康复仪科学技术成果鉴定证书

17.Effects of Brain Function Rehabilitation Apparatus on Cerebral Hemodynamics and Cerebral Function

脑功能康复仪（脑康仪）对脑血流动力学和脑功能的影响

18.Transcranial Magnetic-Electric Encephalopathy Therapeutic Apparatus Blazes a New Path for Physical Therapy of Encephalopathy An Open Letter in Response to Dr. Shilihe Zhuang

经颅磁电脑病治疗仪开辟物理手段治疗脑病新途径——复庄时利和博士的公开信

19.The World Stands on the Eve of the "Physical Revolution in Brain Science" Reflections Following the Open Letter in Reply to Dr. Shilihe Zhuang

世界正处在“脑科学物理革命”的前夜——“复庄时利和博士的公开信”后的思考

20.Outline of the π Program——Aobo Brain Science Initiative

21. Noninvasive Deep Brain Stimulation via Temporally Interfering Electric Fields

22. Method and Application of endogenous neurotransmitter regulation theory

内源性神经递质调控理论方法及应用

23.Therapeutic Effect of Repetitive Transcranial Magnetoelectric Stimulation on Kainic Acid-Induced Epileptic Rats

重复经颅磁电刺激对海人酸致痫鼠的疗效研究

24.Question of Parity Non-Conservation in Weak Interactions

弱相互作用中的宇称不守恒质疑

第三方评价文章——“孙作东质疑杨振宁的论文”

25.Hypothesis of DNA Origami Windmill Tetramer Model Based on Franklin 51 Diagram

基于Franklin 51图的DNA折纸风车四聚体模型假说

26.DNA Origami Windmill Tetramer Model

DNA折纸风车四聚体模型

27.Explanation of Gorky staining selective coloring mechanism based on potassium channel origami windmill model

基于钾离子通道折纸风车模型的高尔基染色选择性着色机制解释

28.Windmill Model: A Unified Explanation Hypothesis for the Unsolved Problem at the Core of the Lock Eye Nebula

风车模型：锁眼星云核心未解难题的统一解释工作假设

29.Cross scale translation of origami windmill model: hypothesis of rotation mechanism driven by inverted conical constrained holes and dynamic locking holes

折纸风车模型的跨尺度平移：倒圆锥形约束孔与动态锁孔驱动的旋转机制假说

30.The Order in the Origami Windmill: How Scientific Conjectures Connect Life and the Universe from DNA to Galaxies

折纸风车中的秩序：从DNA到星系，科学猜想如何连接生命与宇宙

31.From Neuroelectrophysiology to the Continuation of Life Information: A Scientific Perspective on the Survival of Brain Waves and “Consciousness”

从神经电生理到生命信息延续：脑电波与“神识”存续的科学视角探讨

32.Windmill Principle: A Cross-Scale Unification Hypothesis Connecting Life, Universe, and Cognition—Exploring the “Constraint-Rotation-Dynamic Adaptation” Mechanism Based on the Origami Windmill Model

“风车”原理：一个连接生命、宇宙与认知的跨尺度统一性假说——基于折纸风车模型的“约束-旋转-动态适配”机制探索

33.Potassium channel origami windmill model-driven ion microenvironment regulation: A unified mechanism for HeLa cell immortality and Hayflick limit

钾离子通道折纸风车模型驱动的离子微环境调控：海拉细胞永生与海弗利克极限的统一机制

34.0=No, 1=Yes: The Underlying Logic of Origami Windmill Model Decoding Neural Electromagnetic Waves and Life Inheritance

0=No，1=Yes：折纸风车模型解码神经元电磁波与生命传承的底层逻辑

35.The New solution to ion regulation mechanism of ion channel origami windmill model——verification of ion regulation logic based on experiments of squid and dog pseudo tendons

离子通道折纸风车模型的离子调控机制新解——基于枪乌贼与狗伪腱实验的离子调控逻辑印证

36.DNA Tetramer Yin-Yang Pairing Genetic Hypothesis

DNA四聚体阴阳配对遗传假说

37.The Cosmic Windmill Model: A Cross-Scale Unified Functional Topological Framework

宇宙大风车模型：一个跨尺度的统一功能拓扑框架

38.The Rotary Gating Model of Potassium Ion Channels Serves as a Final Veto for the Existence of "Molecular Motors" in Vivo

钾离子通道旋转门控模型对“分子马达”体内存在的终审否决

39.Temporal Dislocation and Theoretical Reconstruction in the History of Science: A Unified Interpretation from Ion Channels to DNA Replication

科学史上的时序错位与理论重构：从离子通道到DNA复制的统一解释

40.A New Explanation of Membrane Potential Based on Dynamic Channel Structures - A Theoretical Deduction Challenging the Hypothesis of Independent Active Transport via Na⁺/K⁺ Pumps

基于动态通道结构的膜电位新解释——对独立钠钾泵主动转运假说的理论推演

41.The Objective Limitations of the Meselson–Stahl Experiment: A Comprehensive Interpretation of Mendelian Pairwise Heredity Based on the Dynamic DNA Tetramer Model

梅塞尔森-斯塔尔实验的客观边界：兼谈DNA动态四聚体模型对孟德尔成对遗传的完整诠释

42.A Unified Interpretation of Mendel’s Law of Paired Inheritance, Morgan’s Chromosome Theory of Genes, and the Dynamic DNA Origami Windmill Tetramer Replication Mechanism—Concurrent Responses to Four Core Academic Doubts in Genetic Paradigms

孟德尔成对遗传法则、摩尔根基因论与DNA动态折纸风车四聚体复制机制统一诠释——兼答遗传学范式四大核心学术质疑

43.Bridging Macro and Micro: From Classical Genetics to the Dynamic DNA Origami Windmill Tetramer Model

贯通宏观与微观：从经典遗传学到DNA动态折纸风车四聚体模型

44.Cellular bioelectrogenetics: coupling mechanism between bioelectric signals and genetic material replication

细胞生物电遗传学：生物电信号与遗传物质复制耦合机制

45.Re-examining the Orch-OR Hypothesis: The "Origin Site" of Quantum Information Underpinning Consciousness May Reside in the Conical Pore of Potassium Ion Channels

重审Orch‑OR假说：意识量子信息的“始发站”，可能在钾离子通道锥形孔

46.The Era of Big Science: Why the Nobel Prize Cherishes That Initial Spark of Insight More Than Ever

大科学时代诺奖为何格外看重最初那一束思想微光

47.A New Interpretation of Cytoplasmic Inheritance and a Series of Controlled Verification Experimental Designs Based on Tong Dizhou’s “Tong Fish” Experiment

从童第周“童鱼”出发：细胞质遗传现象新解与系列对照验证实验构想

48.The Confused Story of Tong Dizhou: Why the "Tong Fish" and Nuclear-Transplanted Fish Are Not the Same Thing

被混淆的童第周：为什么“童鱼”和“移核鱼”不是一回事

49.One Nuclear Envelope, Two Windmill Systems: How Bioelectric Fields Determine the Direction of Cellular Development

一层核膜两套风车：生物电场怎样决定细胞发育走向

50.Invisible Impurities in Extracts: Re-examining the Half-Century Controversy Over the Tong Fish Experiments

提取物里的“隐形杂质”——重新审视童鱼实验的半世纪争议

51.Torn Business Cards and the 3-Billion Base Sequence: Re-examining the Hypothesis of DNA Strand Separation and Replication Through Logic and Probability

撕裂的名片与30亿碱基序列：从逻辑与概率审视DNA拆链复制假说

52.How to Build the First Line of Defense for Scientific Ideas

科学思想如何守住第一道防线

53.Should Judgments on Scientific Truth Be Entirely Left to Scientists?

科学是非应当全部交由科学家评判吗？

54.Origami Windmill Tetramers of Cell Membrane and Nuclear Envelope: A Unified Pathway Linking Electrical Activity and Genetic Regulation

细胞膜与核膜折纸风车四聚体：一条连接电活动与遗传调控的统一通路

55.On How to Define the Boundaries of the Right to Scientific Judgment

科学评判权应当如何界定边界

56.Deduction of Homology Between Cell Membrane and Nuclear Pore Tetramers Based on Evolution Theory and Existing Data

基于进化论与现有资料推演细胞膜、核膜孔四聚体同源性

57.Bioelectrogenetics: The Second Genetic Code Hidden in Membrane Voltage

生物电遗传学：藏在电压里的第二套遗传密码

58.The Tang School, Spark School and Neuron Wi-Fi

汤派、火花派与神经元WiFi

59.Invasive and Non-Invasive Brain Pacemakers: Two Parallel Paths of Neuromodulation Technology

侵入式与非侵入式脑起搏器：两条并行的神经调控技术之路

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